QSAR studies-potent benzodiazepine γ-secretase inhibitors

βSecretase+γSecretase+APP→A42(ADcausingpeptide)This toxic amyloidogenic pathway is to be stopped and to achieve this γ-secretase has been targeted. Making its effect on APP impotent it is possible to curb this toxic product Aβ42.γSecretase(activeform)→inhibitionBenzodiazepineγSecretase(inactiveform)This prevents the formation of Aβ42 and hence could prevent Alzheimer's disease.