Antimycobacterial compounds. Optimization of the BM 212 structure, the lead compound for a new pyrrole derivative class

Previously we have identified BM 212, a pyrrole derivative with good in vitro activity against mycobacteria and a four-feature pharmacophore model derived from it and many other antimycobacterial compounds synthesized by us. On SAR and molecular modeling considerations, we prepared new pyrrole derivatives in the hope of increasing the activity. The microbiological data showed interesting in vitro activity against Mycobacterium tuberculosis.