New antiestrogens from a library screen of homoallylic amides, allylic amides, and C-cyclopropylalkylamides

A new structural scaffold for antiestrogens was identified from the cell-based screening of a 67-member library of homoallylic amides, allylic amides, and C-cyclopropylalkylamides. Several derivatives had activity comparable to that of tamoxifen.