کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10591692 981757 2014 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of several acetylated chitooligosaccharides on antioxidation, antiglycation and NO generation in erythrocyte
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Effects of several acetylated chitooligosaccharides on antioxidation, antiglycation and NO generation in erythrocyte
چکیده انگلیسی
Three kinds of chitooligosaccharides (COS) with different degrees of deacetylation were prepared and named MD90, MD70 and MD50, respectively. Antioxidation, antiglycation and nitric oxide (NO) promotion in erythrocyte of these samples were investigated. The results showed that COS, especially MD90 had obviously inhibitory effects on oxidation and glycation. In addition, MD90 displayed stronger effect on increasing endogenous NO content than both MD70 and MD50, whose degrees of deacetylation were lower. The results indicated that amino group in COS has a certain effect on the activities of COS. As COS have a conformed activity to treat diabetes, the results of this study may be meaningful for further understanding the mechanism of the action.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 24, Issue 16, 15 August 2014, Pages 4053-4057
نویسندگان
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