کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10591715 981760 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides
چکیده انگلیسی
The enoyl acyl-carrier protein reductase (ENR) enzyme is harbored within the apicoplast of apicomplexan parasites providing a significant challenge for drug delivery, which may be overcome through the addition of transductive peptides, which facilitates crossing the apicoplast membranes. The binding site of triclosan, a potent ENR inhibitor, is occluded from the solvent making the attachment of these linkers challenging. Herein, we have produced 3 new triclosan analogs with bulky A- and B-ring motifs, which protrude into the solvent allowing for the future attachment of molecular transporters for delivery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 12, 15 June 2013, Pages 3551-3555
نویسندگان
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