Thiazolidine-2,4-diones derivatives as PPAR-γ agonists: Synthesis, molecular docking, in vitro and in vivo antidiabetic activity with hepatotoxicity risk evaluation and effect on PPAR-γ gene expression

A library of 2,4-thiazolidinedione analogues have been synthesized which exhibited potent in vitro PPAR-γ and in vivo antidiabetic activity without causing any toxicity to liver.