Evaluation of bisindole as potent β-glucuronidase inhibitors: Synthesis and in silico based studies

Bisindole derivatives 1-17 have been synthesized and evaluated for their in vitro β-glucuronidase inhibitory potential. Some of these derivatives showed β-glucuronidase inhibitory activity more potent than the standard d-sachharic acid. In addition, molecular docking studies were also carried out using the GOLD 3.0 program to predict their structure-activity relationship.