Synthesis and optimization of N-heterocyclic pyridinones as catechol-O-methyltransferase (COMT) inhibitors

Synthesis and optimization of N-heterocyclic pyridinones as catechol-O-methyltransferase (COMT) inhibitors

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 26, Issue 12, 15 June 2016, Pages 2952-2956

Zhijian Zhao, Scott T. Harrison, Jeffrey W. Schubert, John M. Sanders, Stacey Polsky-Fisher, Nanyan Rena Zhang, Debra McLoughlin, Christopher R. Gibson, Ronald G. Robinson, Nancy A. Sachs, Monika Kandebo, Lihang Yao, Sean M. Smith, Pete H. Hutson,