Synthesis, cytostatic activity and ADME properties of C-5 substituted and N-acyclic pyrimidine derivatives

The synthesis of 5-alkyl pyrimidine derivatives, 5,6-dihydrofuro[2,3-d]pyrimidines and 5-alkyl N-methoxymethyl pyrimidine derivatives and their cytostatic evaluation are described. The mechanism of antiproliferative effect and ADME profile of 5-(2-chloroethyl)-substituted pyrimidine 3 that exerted the most pronounced cytostatic activity are also reported.