DPMA, a deoxypodophyllotoxin derivative, induces apoptosis and anti-angiogenesis in non-small cell lung cancer A549 cells

DPMA inhibited microtubule formation, induced expression of Bax, cleaved caspase-3, p53 and improve ROS levels, as well as activated cyclinB1 and cdc2. DPMA also inhibited tube formation of VEGF-induced human umbilical vein endothelial cells.