کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10593361 981806 2013 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Design, synthesis and cytotoxicity of novel 3′-N-alkoxycarbonyl docetaxel analogs
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Design, synthesis and cytotoxicity of novel 3′-N-alkoxycarbonyl docetaxel analogs
چکیده انگلیسی
An interesting by-product 9a was identified with very potent cytotoxicity. The structure of 9a was carefully characterized by 1D and 2D NMR and further confirmed by means of synthesis. The preliminary SAR study demonstrated that analogs with (R)-configuration were slightly more potent than analogs with (S)-configuration, and α,α-gem-dimethyl analogs 16g-i exhibited more potent cytotoxicity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 24, 15 December 2013, Pages 6834-6837
نویسندگان
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