کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10594128 | 981821 | 2012 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups](/preview/png/10594128.png)
چکیده انگلیسی
We have synthesized and evaluated a series of novel HCV NS3 protease inhibitors with various P4 capping groups, which include urea, carbamate, methoxy-carboxamide, cyclic carbamate and amide, pyruvic amide, oxamate, oxalamide and cyanoguanidine. Most of these compounds are remarkably potent, exhibiting single-digit to sub-nanomolar activity in the enzyme assay and cell-based replicon assay. Selected compounds were also evaluated in the protease-inhibitor-resistant mutant transient replicon assay, and they were found to show quite different potency profiles against a panel of HCV protease-inhibitor-resistant mutants.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 24, 15 December 2012, Pages 7351-7356
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 24, 15 December 2012, Pages 7351-7356
نویسندگان
Xianfeng Li, Yang Liu, Yong-Kang Zhang, Jacob J. Plattner, Stephen J. Baker, Wei Bu, Liang Liu, Yasheen Zhou, Charles Z. Ding, Suoming Zhang, Wieslaw M. Kazmierski, Robert Hamatake, Maosheng Duan, Lois L. Wright, Gary K. Smith, Richard L. Jarvest,