Synthesis and anti-hyperglycemic activity of hesperidin derivatives

A series of hesperidin derivatives were prepared and identified by IR, 1H NMR, and MS spectra. All the synthetic compounds had been evaluated in vitro and in vivo based on α-glucosidase inhibition, glucose consumption of HepG2 cells and blood glucose level in streptozotocin-induced diabetic mice. The results revealed that all the compounds exhibited the anti-hyperglycemic activities. Compounds 3 and 7a had the excellent inhibition on α-glucosidase as compared to acarbose. Compound 3 could improve the glucose consumption of HepG2 cell and apparently reduce the blood glucose level of the streptozotocin-induced diabetic mice. Compound 3 exhibited the promising anti-hyperglycemic activity.