Folacin C60 derivative exerts a protective activity against oxidative stress-induced apoptosis in rat pheochromocytoma cells

Folacin C60 derivative has been synthesised and characterized in our recent research. As a novel derivative of C60, the folacin C60 derivative is soluble in H2O which behaves as a free radical scavenger. Rat pheochromocytoma cells treated with hydrogen peroxide underwent cytotoxicity and apoptotic death is determined by MTT assay and flow cytometry analysis. The results suggest that folacin C60 derivative has the potential to prevent oxidative stress-induced cell death without evident toxicity.