Novel semicarbazones based 2,5-disubstituted-1,3,4-oxadiazoles: One more step towards establishing four binding site pharmacophoric model hypothesis for anticonvulsant activity

A series of novel semicarbazones based 2,5-disubstituted-1,3,4-oxadiazoles possessing four vital structural features (A) hydrophobic aryl ring system, (HBD) hydrogen binding domain, (D) electron donor moiety and (C) distal aryl ring required for anticonvulsant activity are disclosed. The aryl semicarbazones have been found to possess anticonvulsant activity through GABA mediation.