کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10595238 981861 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structure-based optimization of morpholino-triazines as PI3K and mTOR inhibitors
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Structure-based optimization of morpholino-triazines as PI3K and mTOR inhibitors
چکیده انگلیسی
A virtual screen of our in-house database using various fingerprint techniques returned several triazine hits which were found to be mTOR inhibitors with a slight selectivity over PI3Kα. Using structure-guided lead optimization the inhibitory activity towards mTOR and PI3Kα was increased to the low nanomolar range. Exploiting shape differences in the binding-site allowed for the design of mTOR selective inhibitors. Focus on ligand efficiency ensured the inhibitors retained a low molecular weight and desirable drug-like properties.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 2, 15 January 2012, Pages 1009-1013
نویسندگان
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