کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10595473 | 981862 | 2013 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and cytotoxic activity evaluation of 2,3-thiazolidin-4-one derivatives on human breast cancer cell lines
ترجمه فارسی عنوان
بررسی فعالیت سنتز و فعالیت سیتوتوکسیک مشتقات 2،3-تیازولیدین-4-یک در سلولهای سرطان سینه انسان
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
It is well known that resveratrol (RSV) displayed cancer-preventing and anticancer properties but its clinical application is limited because of a low bioavailability and a rapid clearance from the circulation. Aim of this work was to synthesize pharmacologically active resveratrol analogs with an enhanced structural rigidity and bioavailability. In particular, we have synthesized a library of 2,3-thiazolidin-4-one derivatives in which a thiazolidinone nucleus connects two aromatic rings. Some of these compounds showed strong inhibitory effects on breast cancer cell growth. Our results indicate that some of thiazolidin-based resveratrol derivatives may become a new potent alternative tool for the treatment of human breast cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 17, 1 September 2013, Pages 4990-4995
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 17, 1 September 2013, Pages 4990-4995
نویسندگان
Marina Sala, Adele Chimento, Carmela Saturnino, Isabel M. Gomez-Monterrey, Simona Musella, Alessia Bertamino, Ciro Milite, Maria Stefania Sinicropi, Anna Caruso, Rosa Sirianni, Paolo Tortorella, Ettore Novellino, Pietro Campiglia, Vincenzo Pezzi,