کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10595950 | 981883 | 2013 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cytotoxic scalarane sesterterpenes from a Korean marine sponge Psammocinia sp.
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cytotoxic scalarane sesterterpenes from a Korean marine sponge Psammocinia sp. Cytotoxic scalarane sesterterpenes from a Korean marine sponge Psammocinia sp.](/preview/png/10595950.png)
چکیده انگلیسی
Three novel scalarane sesterterpenes were isolated from a Korean marine sponge, Psammocinia sp., along with four known derivatives. Their structures were elucidated on the basis of NMR, MS and IR spectroscopic data. The three new compounds are 12-deacetoxy-23-hydroxyscalaradial (1), 12-dehydroxy-23-hydroxyhyrtiolide (2) and 12-O-acetyl-16-deacetoxy-23-acetoxyscalarafuran (3), respectively, and the four known compounds are 12-deacetoxy-23-hydroxyheteronemin (4), 12-deacetoxy-23-acetoxy-19-O-acetylscalarin (5), 12-deacetoxy-23-O-acetoxyheteronemin (6) and 12-deacetoxyscalaradial (7). They exhibited cytotoxicity against intractable human cancer cell lines A498, ACHN, MIA-paca and PANC-1, with an IC50 range of 0.4-48 μM.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 8, 15 April 2013, Pages 2336-2339
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 23, Issue 8, 15 April 2013, Pages 2336-2339
نویسندگان
Dongyup Hahn, Dong Hwan Won, Bora Mun, Hiyoung Kim, Chulkyeong Han, Weihong Wang, Taeho Chun, Sunhee Park, Dajeong Yoon, Hyukjae Choi, Sang-Jip Nam, Merrick Ekins, Jungwook Chin, Heonjoong Kang,