Discovery of N-[[1-[2-(tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)-4-piperidyl]methyl]-3,5-dichloro-benzamide as a selective T-type calcium channel (Cav3.2) inhibitor

The design of a novel, peripherally restricted, selective T-type calcium channel (Cav3.2) inhibitors by systematic chemical modifications is described.