Comparison of the cytotoxic effects of enantiopure PPAPs, including nemorosone and clusianone

The separated enantiomers of three PPAPs, including nemorosone, clusianone, and an unnatural 'Type C' derivative, have been screened for activity against HeLa (cervix carcinoma), MIA-PaCa-2 (pancreatic carcinoma), and MCF7 (mamma carcinoma) cancer cell lines. All of the isomers examined gave surprisingly similar results in the screens.