کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10596566 981902 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Newly synthesized bis-benzimidazole derivatives exerting anti-tumor activity through induction of apoptosis and autophagy
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Newly synthesized bis-benzimidazole derivatives exerting anti-tumor activity through induction of apoptosis and autophagy
چکیده انگلیسی
A new series of bis-benzimidazole derivatives were designed and synthesized. They showed significant anti-tumor activity in vitro compared to Hoechst 33258. Among them, the most potent compound 8 exhibited less toxicity than 5-FU on human PBMC. Compound 8 also induced autophagy and apoptosis in HL60 cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 22, Issue 19, 1 October 2012, Pages 6297-6300
نویسندگان
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