New CD1d agonists: Synthesis and biological activity of 6″-triazole-substituted α-galactosyl ceramides

6″-Triazole-substituted-α-galactosyl ceramides 12a-f, 13, 14 and 15 have been synthesised. Along with azide precursor 11, their ability to activate iNKT cells and stimulate the production of IL-2 cytokines in vitro, and IFN-γ and IL-4 cytokines in vivo, has been evaluated.