6′-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the α4β2 nicotinic receptor pharmacophore model

The racemic (±) compound is more potent at the α4β2 nicotinic receptor (Ki = 0.39 nM) than any previously reported bridged nicotinoid, establishing an important role of the 6′-methyl substituent in this pharmacophore model.