Keywords: Natural toxins; Batrachotoxin; Epibatidine; Ultra-performance liquid chromatography/tandem mass spectrometry;
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The binding orientation of epibatidine at α7 nACh receptors
Keywords: Cys-loop; Ion channel; Radioligand; Epibatidine; Agonist; α7 nACh; Nicotinic; Receptor; AChBP; 5-HT; 5-hydroxytryptamine; nACh; nicotinic acetylcholine; GABA; gamma-aminobutyric acid; HEK; human embryonic kidney; AChBP; acetylcholine binding protein; 5HT
A possible desensitized state conformation of the human α7 nicotinic receptor: A molecular dynamics study
Keywords: Epibatidine; Ligand-gated ion channel; Homology modeling; Molecular dynamics; Desensitized state;
Regulation of α4β2α5 nicotinic acetylcholinergic receptors in rat cerebral cortex in early and late adolescence: Sex differences in response to chronic nicotine
Keywords: Chronic nicotine; Adolescence; Nicotinic receptor subtypes; Immunoprecipitation; α5 subunit; EB; epibatidine; mPFC; medial prefrontal cortex; NRS; normal rabbit serum; PN; postnatal day; s.c.; sub-cutaneous;
Lack of GABAB receptors modifies behavioural and biochemical alterations induced by precipitated nicotine withdrawal
Keywords: Nicotine; GABAB receptor; Withdrawal; Anxiety; BDNF; Corticosterone; Epibatidine; Monoamines; Mice; NIC; nicotine; SAL; saline; MEC; mecamylamine; GABA; gamma-aminobutyric acid; DA; dopamine; DOPAC; 3,4-dihydroxyphenylacetic acid; 5-HT; serotonin; 5-HIAA;
3,4-Methylenedioxy-methamphetamine induces in vivo regional up-regulation of central nicotinic receptors in rats and potentiates the regulatory effects of nicotine on these receptors
Keywords: MDMA; Ecstasy; Up-regulation; Nicotinic; Nicotine; Epibatidine
Synthesis and binding affinity at α4β2 and α7 nicotinic acetylcholine receptors of new analogs of epibatidine and epiboxidine containing the 7-azabicyclo[2.2.1]hept-2-ene ring system
Keywords: Neuronal nicotinic acetylcholine receptors; Epibatidine; Epiboxidine; Nicotinic ligands; Binding affinity;
Differential sensitivity of Ctenocephalides felis and Drosophila melanogaster nicotinic acetylcholine receptor α1 and α2 subunits in recombinant hybrid receptors to nicotinoids and neonicotinoid insecticides
Keywords: Ctenocephalides felis; Drosophila melanogaster; Nicotinic acetylcholine receptor; Insect α subunits and chicken β2 subunits; Hybrid receptors; Neonicotinoids; Imidacloprid; Epibatidine
An autoradiographic survey of mouse brain nicotinic acetylcholine receptors defined by null mutants
Keywords: nAChR, nicotinic cholinergic receptor; αBgt, α-bungarotoxin; A-85380, 3-((2S)-azetidinylmethoxy)pyridine; αCtxMII, α-conotoxinMIINicotinic acetylcholine receptor; Null mutant mice; Epibatidine; A-85380; α-Conotoxin MII; α-Bungarotoxin
Structure–activity relationships of N-substituted ligands for the α7 nicotinic acetylcholine receptor
Keywords: Nicotinic acetylcholine receptors; Neuronal nicotinic receptors; Nicotinic agonist; Nicotine; Epibatidine; Neuroscience
86Rb+ efflux mediated by α4β2*-nicotinic acetylcholine receptors with high and low-sensitivity to stimulation by acetylcholine display similar agonist-induced desensitization
Keywords: Nicotinic acetylcholine receptor; Desensitization; Nicotine; Epibatidine; Cytisine; Methylcarbachol
Modulatory role of estradiol in nicotinic antinociception in adult female rats
Keywords: Antinociception; Estradiol; Epibatidine; Nicotinic acetylcholine receptor; Spinal cord;
Brain cyclooxygenase and prostanoid TP receptors are involved in centrally administered epibatidine-induced secretion of noradrenaline and adrenaline from the adrenal medulla in rats
Keywords: Epibatidine; Brain nicotinic acethylcholine receptor; Cyclooxygenase; Prostanoid TP receptor; Adrenal medulla
Haeme oxygenase-1 overexpression via nAChRs and the transcription factor Nrf2 has antinociceptive effects in the formalin test
Keywords: Epibatidine; Haeme oxygenase-1; Pain; Inflammation;
Expression of nicotinic acetylcholine receptors and subunit messenger RNAs in the enteric nervous system of the neonatal rat
Keywords: gastrointestinal; nicotine; myenteric plexus; submucosal; in situ hybridization; epibatidine; CNS; central nervous system; ENS; enteric nervous system; fEPSP; fast excitatory postsynaptic potential; GI; gastrointestinal; nAChR; nicotinic acetylcholine rec
In vivo effects of 3-iodocytisine: Pharmacological and genetic analysis of hypothermia and evaluation of chronic treatment on nicotinic binding sites
Keywords: Nicotinic acetylcholine receptors; Null mutant mice; 3-iodocytisine; Hypothermia; Epibatidine; α-Bungarotoxin
3′-Fluoro substitution in the pyridine ring of epibatidine improves selectivity and efficacy for α4β2 versus α3β4 nAChRs
Keywords: Recombinant neuronal nicotinic receptors; Epibatidine; Epibatidine analogs; Whole-cell; Nicotine-induced analgesia; Binding
Epibatidine binds to four sites on the Torpedo nicotinic acetylcholine receptor
Keywords: Nicotinic; Acetylcholine; Epibatidine; α-Bungarotoxin; Suberyldicholine; Receptor binding sites; Receptor function; Radiolabelled ligand binding; Torpedo californica;
Characterization of ganglionic acetylcholine receptor autoantibodies
Keywords: Autonomic; Myasthenia; Neuronal; Subunits; Epibatidine; Bungarotoxin
Electrophysiologic effects of systemic and locally infused epibatidine on locus coeruleus neurons
Keywords: Epibatidine; Locus coeruleus; Electrophysiology; Analgesia; Dorsal raphe;
Norchloro-fluoro-homoepibatidine (NCFHEB) — A promising radioligand for neuroimaging nicotinic acetylcholine receptors with PET
Keywords: Positron emission tomography; Blood-brain barrier; Epibatidine; Stereoselectivity; Subtype specificity
Role of negatively charged amino acids in β4 F-loop in activation and desensitization of α3β4 rat neuronal nicotinic receptors
Keywords: Nicotinic acetylcholine receptor; α3β4; Epibatidine; F-loop
β2â and β4â nicotinic acetylcholine receptor expression changes with progressive parkinsonism in non-human primates
Keywords: Macaca fascicularis; Macaca mulatta; Macaca nemestrina; Epibatidine; A85380;
A-366833: A novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane α4β2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models
Keywords: nAChR; Nicotine; Epibatidine; A-366833; Pain; Emesis
Gene targeting demonstrates that α4 nicotinic acetylcholine receptor subunits contribute to expression of diverse [3H]epibatidine binding sites and components of biphasic 86Rb+ efflux with high and low sensitivity to stimulation by acetylcholine
Keywords: Null mutant mice; Nicotinic acetylcholine receptor; Epibatidine; 86Rb+ efflux; Cytisine; Dihydro-β-erythroidine
Differential nicotinic regulation of the nigrostriatal and mesolimbic dopaminergic pathways: Implications for drug development
Keywords: Nicotine; Epibatidine; Dopamine; Nigrostriatal pathway; Mesolimbic pathway; Rotational behavior; Locomotor activity; Place preference; Parkinson's disease; Schizophreniaα-Ctx, α-conotoxin; CNS, central nervous system; COMT, catechol-O-methyl transferase;
Desymmetrization of meso 7-aza-2,3-bis(phenylsulfonyl) bicyclo[2.2.1]hept-2-ene: a re-examination. Kinetic resolution of racemic 3-arylsulfonyl-7-aza-2-bromobicyclo[2.2.1]hepta-2,5-dienes
Keywords: Desymmetrization; Kinetic resolution; Epibatidine; 7-Azabicyclo[2.2.1]heptane; Sulfones;
Effects of paraformaldehyde fixation on nicotinic acetylcholine receptor binding in adult and developing rat brain sections
Keywords: Epibatidine; Alpha-bungarotoxin; Nicotine; Autoradiography
Inhibitory effect of hemicholinium-3 on presynaptic nicotinic acetylcholine receptors located on the terminal region of myenteric motoneurons
Keywords: Nicotinic acetylcholine receptor; Enteric nervous system; Ileum; Longitudinal muscle strip; Epibatidine
The locus coeruleus nucleus as a site of action of the antinociceptive and behavioral effects of the nicotinic receptor agonist, epibatidine
Keywords: Epibatidine; Analgesia; Locus coeruleus; Pain; Behavior
An autoradiographic analysis of rat brain nicotinic receptor plasticity following dietary choline modification
Keywords: α7 nAChR; Cholinergic; Acetylcholine; Morris Water Maze; Up-regulation; Bungarotoxin; Epibatidine
Selective nicotinic acetylcholine receptor subunit deficits identified in Alzheimer's disease, Parkinson's disease and dementia with Lewy bodies by immunoprecipitation
Keywords: Nicotinic acetylcholine receptors; Subunits; Human brain; Alzheimer's disease; Parkinson's disease; Dementia with Lewy bodies; Immunoprecipitation; Epibatidine; αBungarotoxin; Choline acetyltransferase
6â²-Methylpyrido[3,4-b]norhomotropane: synthesis and outstanding potency in relation to the α4β2 nicotinic receptor pharmacophore model
Keywords: Nicotinic receptor; Pharmacophore model; Pyridonorhomotropane; Epibatidine; Bridged nicotinoid;
Time and brain region specific up-regulation of low affinity neuronal nicotinic receptors during chronic nicotine administration in mice
Keywords: α7 nicotinic receptor; Neuronal nicotinic receptor; Nicotine; Receptor binding; Methyllycaconitine; Epibatidine;
Nicotine and epibatidine alter differently nomifensine-elevated dopamine output in the rat dorsal and ventral striatum
Keywords: Nicotine; Epibatidine; Nomifensine; Dopamine; Nucleus accumbens; Caudate-putamen; In vivo microdialysis;
Effects of nicotine and epibatidine on locomotor activity and conditioned place preference in rats
Keywords: Nicotine; Epibatidine; Locomotor activity; Conditioned place preference; Rat;
Nicotinic modulation of GABAergic synaptic transmission in the spinal cord dorsal horn
Keywords: Neurotransmitters, Modulators, Transporters, and Receptors; Acetylcholine Receptors: Nicotinic; Nicotine; Analgesia; Epibatidine; Nicotinic acetylcholine receptor; Long-term depression;
From ligand design to therapeutic efficacy: the challenge for nicotinic receptor research
Keywords: Pharmaceutical Science; Drug Discovery; Bioinformatics; Molecular Medicine; nicotine; epibatidine; cytisine; nicotinic acetylcholine receptor; nicotinic drug;
Pharmacological profiles of recombinant and native insect nicotinic acetylcholine receptors
Keywords: Drosophila; Epibatidine; Hybrid nicotinic receptor of Drosophila α2 or Myzus α2 and rat β2 subunits; Imidacloprid; Neonicotinoids; α-BGT; α-bungarotoxin; Bmax; maximal binding capacity; CLO; clothianidin; Dα2/Rβ2; hybrid receptor consisting of Dros
Phosphorimaging detection and quantitation for isotopic ion flux assays
Keywords: Nicotine; Acetylcholine receptor; Epibatidine; Radioisotope tracing; Sodium channel; Sodium influx; Rubidium efflux; Batrachotoxin; Autoradiography;