کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10597119 | 981955 | 2013 | 28 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dextran-based cyclodextrin polymers: Their solubilizing effect and self-association
ترجمه فارسی عنوان
پلیمرهای سیکلوکودکسترین مبتنی بر دکستران: اثرات حلزونیشان و همبستگی خودشان
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
چکیده انگلیسی
Cyclodextrins and their water-soluble derivatives are excellent solubilizers and stabilizers and widely used as enabling pharmaceutical excipients. However, still new cyclodextrin derivatives are being designed and synthesized in an effort to improve their physicochemical properties. In this study physicochemical and self-associating characteristics of dextran-based cyclodextrin polymers, with ether or ester linkage between the β-cyclodextrin and the dextran backbone, were investigated. Methods applied include phase-solubility studies, permeation studies and dynamic light scattering. Results with a model drug, hydrocortisone, showed that the solubilization and binding efficiency slowly declined with increasing molecular weight. The degree of substitution had significant effect on the properties, making the polymers with ether linkage more favorable. Self-association of the drug-polymer complexes was observed, although the instability can hamper their utilization
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 97, Issue 2, 12 September 2013, Pages 635-642
Journal: Carbohydrate Polymers - Volume 97, Issue 2, 12 September 2013, Pages 635-642
نویسندگان
Zoltán Fülöp, Thorbjørn T. Nielsen, Kim L. Larsen, Thorsteinn Loftsson,