کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10597134 | 981955 | 2013 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Phosphorylation and anti-tumor activity of exopolysaccharide from Lachnum YM120
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Phosphorylated polysaccharide PLEP-1a, with the PO43â content of 6.39%, was prepared from LEP-1a by phosphorylation. IR, 13C NMR and 31P NMR results of PLEP-1a showed that the original basic structure of the polysaccharide was not changed, and the H2PO3 group was linked at C6 of LEP-1a. The results of anti-tumor experiments in vivo showed that 100 mg/kg and 400 mg/kg of LEP-1a could significantly improve the food consumption, body weight, tumor inhibition rate and thymus index of S180 sarcoma mice, and increase the levels of SOD, IL-2 and TNF-α in mice blood serum, indicating that LEP-1a had an excellent anti-tumor activity. Furthermore, PLEP-1a had a significantly enhanced inhibitory effect on S180 sarcoma mice than LEP-1a, suggesting that phosphorylation is an effective way of improving the biological activity of LEP-1a.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 97, Issue 2, 12 September 2013, Pages 690-694
Journal: Carbohydrate Polymers - Volume 97, Issue 2, 12 September 2013, Pages 690-694
نویسندگان
Ming Ye, Ru-yue Yuan, Yun-long He, Zhan-zhan Du, Xiao-jing Ma,