کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10597151 981955 2013 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mussel-inspired modification of dextran for protein-resistant coatings of titanium oxide
ترجمه فارسی عنوان
اصلاح الماس مضر دکستران برای پوشش مقاوم در برابر پروتئین اکسید تیتانیوم
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
Surface modification of inorganic materials to prevent non-specific protein adsorption is critically important for developing a biocompatible materials' platform for medical implantation, diagnostics, and therapeutics. Here we report mussel-inspired chemical modification of dextran for anti-fouling coatings of metal oxide. Catechols are conjugated to dextran via a carbamate ester linkage, producing catechol-grafted dextran with a grafting density of 7.3 mol.%. Titanium dioxide (TiO2) is coated with the catechol-grafted dextran, and the anti-fouling effect of dextran coatings is examined by using the adsorption of human serum albumin. The mussel-inspired dextran coatings show excellent resistance to non-specific protein adsorption: the adsorption equilibrium constant (K) is 0.69 L g−1 for dextran-coated TiO2 while that for pristine TiO2 surface is 3.53 L g−1. This study suggests that catechol-grafted dextran is a promising material for effective anti-fouling coatings of implantable inorganic materials.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 97, Issue 2, 12 September 2013, Pages 753-757
نویسندگان
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