Purification, characterization and anti-proliferation activity of polysaccharides from Flammulina velutipes

► Isolation and characterization of two polysaccharides from Flammulina velutipes. ► Anti-proliferation activities of FVP-1 and FVP-2 against human BGC-823 and A549 cells. ► FVP-1 and FVP-2 exhibited strong antiproliferative potency in BGC-823 cell. ► Anti-proliferation activity was correlated with chemical structures of both polysaccharides.