کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10600191 | 982080 | 2005 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Chitooligosaccharides as a novel β-secretase inhibitor
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
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چکیده انگلیسی
Nine kinds of hetero-chitooligosaccharides (hetero-COSs) with different degrees of deacetylation and molecular weights were prepared using an ultrafiltration (UF) membrane reactor system. In addition, their sulfated derivatives were also synthesized by a method using trimethylamine-sulfur trioxide to investigate the functional group of COSs on β-secretase inhibitory activity. 90-MMWCOSs-I, which are 90% deacetylated COSs passed through the 5 kDa membrane but not passed through the 3 kDa membrane, exhibited the highest β-secretase inhibitory activity (25-42 μM) based on molecular weight of 3 and 5 kDa. The inhibition pattern of the inhibitor was found to be a non-competitive by Dixon plot, and Ki of 90-MMWCOSs-I was 3.87-6.47 μM. Therefore, the data of this research suggest that 90-MMWCOSs-I is a good candidate target molecule to inhibit β-secretase.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 61, Issue 2, 4 August 2005, Pages 198-202
Journal: Carbohydrate Polymers - Volume 61, Issue 2, 4 August 2005, Pages 198-202
نویسندگان
Hee-Guk Byun, Yong-Tae Kim, Pyo-Jam Park, Xinli Lin, Se-Kwon Kim,