Novel chitosan derivative for temperature and ultrasound dual-sensitive liposomal microbubble gel

► We design a novel N-cholesteryl hemisuccinate-O-sulfate chitosan (NCHOSC). ► We developed a liposomal microbubble gel with chitosan/glycerol phosphate. ► NCHOSC was carried to modified liposomal microbubble gel to enhance stability. ► The ultrasound-sensitive induced release of curcumin was about 85%. ► The anti-tumor efficacy in vivo by ultrasound suppressed tumor growth efficiently.