The preparation optimization and immune effect of epimedium polysaccharide-propolis flavone liposome

► Preparation conditions of EPL were optimized by response surface method. ► The optimal preparation condition for EPL was set up. ► EPL could significantly promote T and B lymphocytes proliferation. ► EPL could promote mRNA expression of IL-2 and IL-6 and secretion of IgG and IgM.