Extraction optimization of Angelica sinensis polysaccharides and its antioxidant activity in vivo

► Extraction of Angelica sinensis polysaccharides was optimized by RSM. ► Optimum operational conditions for maximizing polysaccharides yield (5.6%) were achieved. ► Hepatoprotective activity of ASP was evaluated. ► ASP substantially elevated serum enzymatic levels of serum AST, ALT and ALP. ► ASP significantly increased the levels of antioxidant enzymes.