Amphiphilic N-(2,3-dihydroxypropyl)-chitosan-cholic acid micelles for paclitaxel delivery

► Chitosan derivative, N-(2,3-dihydroxypropyl)-chitosan-cholic acid was synthesized. ► Spherical chitosan derivative micelle was prepared and characterized by DLS and TEM. ► PTX released from PTX loaded chitosan derivative micelles in a sustainable manner. ► PTX loaded chitosan derivative micelle showed good antitumor activity to MCF-7 cells.