Galactosylated chitosan-polycaprolactone nanoparticles for hepatocyte-targeted delivery of curcumin

► Galactosylated chitosan-polycaprolactone is synthesized for delivery of curcumin. ► Initial load of curcumin in the resulting nanoparticles reaches around 6%. ► Curcumin release from nanoparticles is controlled by polycaprolactone component. ► Nanoparticles have hepatocyte-targeted specificity toward HepG2 cells. ► Bioavailability of curcumin can be greatly improved using these nanoparticles.