Reversible pH-responsive aggregates based on the self-assembly of functionalized POSS and hyaluronic acid

► Hyaluronic acid and POSS nanaoparticals can form reversible pH-induced aggregates. ► Micelles, sacs and membranes have been observed in this hybrid system. ► Sac after defect can be resealed by triggering additional self-assembly. ► The self-sealing macroscopic structure offer opportunities in many areas.