Construction of hyaluronic acid noisome as functional transdermal nanocarrier for tumor therapy

► Hyaluronic acid niosome as functional transdermal carrier for tumor therapy. ► HA-niosome has small size, elastic multilayer structure and hydrophilic interface. ► The incorporation of HA promotes the endocytosis of nanocarrier by tumor cell. ► HA-niosome is efficient and secure for transdermal permeation. ► HA-niosome is potential carrier for tumor therapy by percutaneous administration.