ZrO2 surface chemically coated with hyaluronic acid hydrogel loading GDF-5 for osteogenesis in dentistry

► We prepared ZrO2 disks surface-modified with pcHAgel containing GDF-5 and BMP-2, respectively. ► We found that ZrO2-4-7 are good candidates that can effectively release as well as contain GDF-5 and BMP-2. ► It was found that GDF-5 is an effective alternative to aid new bone formation in vitro as compared to BMP-2.