Agaricus bisporus fucogalactan: Structural characterization and pharmacological approaches

► A fucogalactan (EFP-Ab) from A. bisporus was characterized structurally. ► EFP-Ab inhibited significantly inflammatory pain caused by formalin injection. ► Lethality induced by CLP was decreased by 40%. ► iNOS and COX-2 protein expression were markedly decreased. ► EFP-Ab has significant anti-sepsis, antinociceptive and anti-inflammatory actions.