Bioactive glasses-incorporated, core-shell-structured polypeptide/polysaccharide nanofibrous hydrogels

► Bioglass particles are incorporated in gelatin nanofibers via phase separation. ► The nanofibers are coated by chitosan-hyaluronic acid by electrostatic crosslinking. ► The composite nanofibers exhibit excellent structural stability in aqueous solution. ► The bioactive inorganic ions could readily release from the composite hydrogel. ► The bioactive hydrogel affords a close biomimicry to the natural soft tissues.