Comb-like ionic complexes of hyaluronic acid with alkyltrimethylammonium surfactants

► Hyaluronic acid with alkyltrimethylammonium surfactants form stable ionic complexes with a comb-like architecture. ► Comb-like alkyltrimethylammonium-polyhyaluronate complexes melt at temperatures between 50 and 70 °C ► Comb-like alkyltrimethylammonium-polyuhyaluronate complexes are arranged in a biphasic amphiphilic structure.