Polysaccharides from Bupleurum chinense impact the recruitment and migration of neutrophils by blocking fMLP chemoattractant receptor-mediated functions

► BCPs, the polysaccharides from Bupleurum chinense, impact the recruitment and migration of neutrophils. ► BCPs significantly blocks the fMLP chemoattractant receptor-mediated functions, including regulation of affinity and avidity of β2 integrin, actin polymerization, and Vav1 and Rac1 activation. ► We provide novel mechanistic insights into the poorly understood signaling network that polysaccharides interfere with the migration of leukocytes to inflammatory sites.