Chitosan-hyaluronan/nano chondroitin sulfate ternary composite sponges for medical use

► A biocompatible and biodegradable chitosan-HYA/nCS composite sponge was developed. ► The nanocomposite sponge showed optimum porosity, swelling and biodegradation. ► These sponges showed enhanced blood clotting and platelet activation. ► Nanocomposite sponges showed enhanced cell viability, attachment and proliferation.