Benznidazole drug delivery by binary and multicomponent inclusion complexes using cyclodextrins and polymers

► Benznidazole is the only drug available for Chagas disease treatment. ► Benznidazole has high toxicity due to its low aqueous solubility. ► Cyclodextrins are tools for enhancing nonpolar drugs' dissolution rate. ► Cyclodextrins are an alternative to reduce the Benznidazole toxicity. ► The product developed has feasibility of industrial-scale production and low cost.