Nano-hybrid carboxymethyl-hexanoyl chitosan modified with (3-aminopropyl)triethoxysilane for camptothecin delivery

► Successful synthesis of a new silane-modified amphiphilic chitosan (CA). ► The CA showed self-assembly capability to effectively entrap anti-cancer molecules. ► The CA exhibited finely tunable drug release behaviour of camptothecin. ► The CA showed excellent cytocompatibility and cellular internalization towards ARPE-19 cells. ► This new class of hybrid biomaterials can be used for drug delivery application.