Self-aggregates of cholesterol-modified carboxymethyl konjac glucomannan conjugate: Preparation, characterization, and preliminary assessment as a carrier of etoposide

► Novel amphiphilic conjugates based on polysaccharide were synthesized. ► The cac values of self-aggregates formed by conjugates was comparatively low. ► The self-aggregates exhibit a pH-and ionic strength-dependent properties. ► The release behavior of drug-loaded self-aggregates exhibit a sustained release.