Investigations on skin permeation of hyaluronic acid based nanoemulsion as transdermal carrier

► An alcohol free hyaluronic acid based nanoemulsion as transdermal carrier. ► HA nanoemulsion penetrates across stratum corneum and diffuse deep into dermis. ► Permeation is primarily achieved by intercellular and follicular pathways. ► No irritation has been found in dermis and skin surface. ► HA nanoemuslion has desirable hydration capacity.