Anti-metastatic and anti-angiogenic activities of sulfated polysaccharide of Sepiella maindroni ink

► Previous study demonstrated that SIP-SII had antimetastatic activity in vitro. ► SIP-SII significantly inhibited melanoma metastasis in vivo. ► SIP-SII inhibited angiogenesis in chick chorioallantoic membrane assay. ► SIP-SII inhibited the expression of ICAM-1 and bFGF both in vitro and in vivo.