The effect of nanoparticles on gastrointestinal release from modified κ-carrageenan nanocomposite hydrogels

► We synthesized silver and magnetite nanoparticles in modified κ-carrageenan hydrogels. ► Impact nanoparticles loading and genipin cross-linking on GIT release is studied. ► The most suitable nanocomposite drug carrier is introduced. ► Using nanofillers drug release in intestine is improve and minimized in the stomach. ► Genipin and nanofiller loading can significantly improve the targeted release.