Inhibition on hepatitis B virus e-gene expression of 10-23 DNAzyme delivered by novel chitosan oligosaccharide-stearic acid micelles

► DrzBC blocks the HBeAg expression with problem on exogenous delivery. ► CSSA micelles are used as a delivery system for DrzBC. ► CSSA/DrzBC inhibit HBeAg expression better than Lipofectamine™ 2000/DrzBC. ► CSSA/DrzBC complex is a promising effective system for inhibiting HBeAg expression.