کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10603101 | 982436 | 2011 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
β-Cyclodextrin grafting hyperbranched polyglycerols as carriers for nasal insulin delivery
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We prepared a β-CD functionalized hyperbranched polyglycerol (HPG) with the purpose of enhancing the nasal transport of insulin in rats. Insulin-loaded HPG-g-CD nanoparticles (NPs) were prepared and the size of the NPs ranged from 198 to 340 nm with a positive charge. The NPs exhibited a great capacity of associating insulin, reaching the efficiency as high as 88.21%. In vitro release showed that the release rate of insulin was much faster under acidic condition than physiological condition. In vitro cytotoxicity against Caco-2 cells showed that HPG-g-CDs had good biocompatibility. The in vivo evaluation in rats demonstrated that insulin-loaded HPG-g-CD NPs had the ability to significantly decrease the blood glucose concentrations. Furthermore, the capability of HPG-g-CD NPs to cross the nasal mucosal epithelia was proved by confocal laser scanning microscopy (CLSM). Consequently, the results suggest that the HPG-g-CD NPs are promising carriers for nasal insulin delivery.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 84, Issue 4, 2 April 2011, Pages 1419-1425
Journal: Carbohydrate Polymers - Volume 84, Issue 4, 2 April 2011, Pages 1419-1425
نویسندگان
Xuejiao Zhang, Xinge Zhang, Zhongming Wu, Xiujun Gao, Shujun Shu, Zhen Wang, Chaoxing Li,